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Hilchot Tefilla - Significance of Shir Hashirim
שְׁנֵ֥י שָׁדַ֛יִךְ כִּשְׁנֵ֥י עֳפָרִ֖ים תְּאוֹמֵ֣י צְבִיָּ֑ה הָרוֹעִ֖ים בַּשּׁוֹשַׁנִּֽים׃
Your breasts are like two fawns,
Twins of a gazelle,
Browsing among the lilies.

...כָּל כִּתְבֵי הַקֹּדֶשׁ מְטַמְּאִין אֶת הַיָּדַיִם... אָמַר רַבִּי עֲקִיבָא... אֵין כָּל הָעוֹלָם כֻּלּוֹ כְדַאי כַּיּוֹם שֶׁנִּתַּן בּוֹ שִׁיר הַשִּׁירִים לְיִשְׂרָאֵל, שֶׁכָּל הַכְּתוּבִים קֹדֶשׁ, וְשִׁיר הַשִּׁירִים קֹדֶשׁ קָדָשִׁים

(5) A scroll on which the writing has become erased and eighty-five letters remain, as many as are in the section beginning, "And it came to pass when the ark set forward" (Numbers 10:35-36) defiles the hands. A single sheet on which there are written eighty-five letters, as many as are in the section beginning, "And it came to pass when the ark set forward", defiles the hands. All the Holy Scriptures defile the hands. The Song of Songs and Kohelet (Ecclesiastes) defile the hands. Rabbi Judah says: the Song of Songs defiles the hands, but there is a dispute about Kohelet. Rabbi Yose says: Kohelet does not defile the hands, but there is a dispute about the Song of Songs. Rabbi Shimon says: [the ruling about] Kohelet is one of the leniencies of Bet Shammai and one of the stringencies of Bet Hillel. Rabbi Shimon ben Azzai said: I have received a tradition from the seventy-two elders on the day when they appointed Rabbi Elazar ben Azariah head of the academy that the Song of Songs and Kohelet defile the hands. Rabbi Akiba said: Far be it! No man in Israel disputed that the Song of Songs [saying] that it does not defile the hands. For the whole world is not as worthy as the day on which the Song of Songs was given to Israel; for all the writings are holy but the Song of Songs is the holy of holies. If they had a dispute, they had a dispute only about Kohelet. Rabbi Yohanan ben Joshua the son of the father-in-law of Rabbi Akiva said in accordance with the words of Ben Azzai: so they disputed and so they reached a decision.

וְסֵפֶר — מַאי טַעְמָא גְּזַרוּ בֵּיהּ רַבָּנַן טוּמְאָה? — אָמַר רַב מְשַׁרְשְׁיָא: שֶׁבִּתְחִלָּה הָיוּ מַצְנִיעִין אוֹכָלִין דִּתְרוּמָה אֵצֶל סֵפֶר תּוֹרָה, וַאֲמַרוּ: הַאי קֹדֶשׁ וְהַאי קֹדֶשׁ. כֵּיוָן דְּקָחָזוּ דְּקָאָתוּ לִידֵי פְסֵידָא, גְּזַרוּ בֵּיהּ רַבָּנַן טוּמְאָה.

The Gemara explains the next case in the mishna: And a Torah scroll; what is the reason the Sages decreed impurity upon it? Rav Mesharshiya said: Since at first, ignorant priests would conceal teruma foods alongside the Torah scroll, and they said in explaining that method of storage: This is sacred and that is sacred, and it is appropriate that they be stored together. Since the Sages saw that they were coming to ruin, as the mice who were attracted to the teruma foods would also gnaw at the Torah scrolls, the Sages decreed impurity upon it. Once they issued the decree of impurity on the Torah scroll, the priests no longer placed teruma near it.
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